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KMID : 0358619930270010107
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Korean Journal of Physiology
1993 Volume.27 No. 1 p.107 ~ p.114
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Low-Voltage Activated Current Carried via T-Type Channels in the Mouse Egg
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Yang Young-Sun
Hong Seong-Geun
Park Choon-Ok
Park Young-Geun
Cho Soo-Wan
Cheong Seung-Jin
Haan Jae-Hee
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Abstract
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Most of voltage operated channels can be divided into three types (T-, N-, and L-type), according to the electrical and pharmacological properties. Their distribution is closely related to cell specific functions. Properties of the voltage activated current in mouse eggs were examined to classify channel types and to deduce the function by using whole cell voltage clamp technique. currents appeared below -40 mV and reached a maximum at -15 mV (half maximum was -31 mV), then decayed rapidly (inactivation time constant ms at -10 mV within 50 ms after the onset of step depolarization. Activation and inactivation of the channel was steeply dependent on voltage, in a relatively low range of half maximum of activation was -31 mV and that of inactivation was -39 mV, respectively. This current was not decreased significantly by nifedipine, a specific dihydropyridine channel blocker in the range of The inhibitory effect of current was greater than that of The conductance of through the channel was equal to or lower than that of These results implied that current activated at a lower voltage in the mouse egg is carried via a channel with similar properties that of the T-type channel.
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KEYWORD
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Mouse egg, current, channel, T-type, Whole-cell voltage-clamp
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